Related references
Note: Only part of the references are listed.Bim expression is reduced in human cutaneous melanomas
Derek L. Dai et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Mutant B-RAF mediates resistance to anoikis via Bad and Bim
K. Boisvert-Adamo et al.
ONCOGENE (2008)
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
James Tsai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Small-Molecule Inhibitors of Bcl-2 Family Proteins as Therapeutic Agents in Cancer
Ramzi Mohammad et al.
Recent Patents on Anti-Cancer Drug Discovery (2008)
Bim and the pro-survival bcl-2 proteins - Opposites attract, ERK repels
Katherine E. Ewings et al.
CELL CYCLE (2007)
Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
Yu Fang Wang et al.
CLINICAL CANCER RESEARCH (2007)
Oncogenic BRAF regulates β-Trcp expression and NF-κB activity in human melanoma cells
J. Liu et al.
ONCOGENE (2007)
Melanoma biology and new targeted therapy
Vanessa Gray-Schopfer et al.
NATURE (2007)
Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis
A. R. Ramjaun et al.
ONCOGENE (2007)
A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species
Monique Verhaegen et al.
CANCER RESEARCH (2006)
p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65
Beibei Cai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma
Vikas K. Goel et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF
C Christensen et al.
ONCOGENE (2005)
Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery
N Thompson et al.
CURRENT OPINION IN PHARMACOLOGY (2005)
Pharmacologic inhibition of RAF→MEK→ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
S Gysin et al.
CANCER RESEARCH (2005)
G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression
NL Collins et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Mutant V599EB-RAF regulates growth and vascular development of malignant melanoma tumors
A Sharma et al.
CANCER RESEARCH (2005)
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
EE Patton et al.
CURRENT BIOLOGY (2005)
Toxic proteins released from mitochondria in cell death
X Saelens et al.
ONCOGENE (2004)
Role of Bim in the survival pathway induced by Raf in epithelial cells
M Marani et al.
ONCOGENE (2004)
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan et al.
CELL (2004)
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
H Tsao et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2004)
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands
CL Day et al.
BIOCHEMICAL JOURNAL (2004)
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
MJ Reginato et al.
NATURE CELL BIOLOGY (2003)
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
LA Allan et al.
NATURE CELL BIOLOGY (2003)
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
R Ley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Apoptosis and melanoma chemoresistance
MS Soengas et al.
ONCOGENE (2003)
High frequency of BRAF mutations in nevi
PM Pollock et al.
NATURE GENETICS (2003)
Mutations of the BRAF gene in human cancer
H Davies et al.
NATURE (2002)
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist bim
P Bouillet et al.
DEVELOPMENTAL CELL (2001)
Induction of β3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway
D Woods et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Analysis of the transcriptional program induced by Raf in epithelial cells
A Schulze et al.
GENES & DEVELOPMENT (2001)
Opposing effects of Ras on p53:: Transcriptional activation of mdm2 and induction of p19ARF
S Ries et al.
CELL (2000)