Journal
PHYTOTHERAPY RESEARCH
Volume 29, Issue 3, Pages 423-433Publisher
WILEY
DOI: 10.1002/ptr.5269
Keywords
allergic rhinitis; ovalbumin; histamine; type-A procyanidin polyphenols; Cinnamomum zeylanicum bark
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Funding
- Indus Biotech Private Limited, Pune, India
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The objective of the present work was to evaluate anti-allergic effects of intranasal administration of type-A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP-CZ) in ovalbumin (OVA)-induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1-G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2-G6) were sensitized with OVA (500L solution, intraperitoneal) on alternate days for 13days and had twice daily intranasal treatment from day 14-21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5mg/mL, 20L/nostril) and G4-G6 received TAPP-CZ (3, 10 and 30 mu g/kg in nostril), respectively. On day 21, mice were challenged with OVA (5L/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP-CZ (10 and 30 mu g/kg in nostril) showed significant attenuation in OVA-induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP-CZ showed anti-allergic efficacy in animal model of AR. Copyright (c) 2014 John Wiley & Sons, Ltd.
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