Journal
PHYTOTHERAPY RESEARCH
Volume 27, Issue 2, Pages 244-250Publisher
WILEY
DOI: 10.1002/ptr.4691
Keywords
Scutellaria baicalensis extracts; AMPK; anti-obesity; anti-hypertriglyceride; db; db
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Funding
- Korea Institute of Oriental Medicine [K11070]
- Korea government (MEST)
- National Research Council of Science & Technology (NST), Republic of Korea [K11070] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Scutellaria baicalensis has been extensively employed for the clinical treatment of hyperlipidemia, atherosclerosis, hypertension, dysentery, inflammatory diseases, and the common cold. The present study was performed to investigate the anti-obesity and anti-dyslipidemia effect of Scutellaria baicalensis extracts (SBE) in type 2 diabetic db/db mice. Male db/db mice were divided into three groups (n=5) and orally administrated vehicle (control), SBE 10, and 100mg/kg body weight/day for 4weeks everyday. Administration of SBE improves weight gain, hypertriglyceridemia, and hyperinsulinemia in db/db mice. In obese db/db mice, SBE treatment also reduced plasma alanine aminotransferase levels. In the livers of db/db mice, SBE promoted 5' AMP-activated protein kinase activity and restored metabolic process and insulin signaling pathways. Our data demonstrate that SBE exerts potent anti-obesity and anti-hypertriglyceride effects suggesting its useful potential function as adjuvant therapeutic agent for the treatment of weight gain and hypertriglyceridemia. Copyright (c) 2012 John Wiley & Sons, Ltd.
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