Damnacanthal from the Congolese Medicinal Plant Garcinia huillensis has a Potent Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cells

Screening of eight Congolese medicinal plants showed that the CHCl3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 mu g/mL and 13.8 mu g/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 mu g/mL) and Securidaca longepedunculata (PC50 = 23.4 mu g/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC50 = 4.46 mu m and 3.77 mu m, respectively). Copyright (c) 2012 John Wiley & Sons, Ltd.