Journal
PHYTOTHERAPY RESEARCH
Volume 26, Issue 12, Pages 1920-1926Publisher
WILEY-BLACKWELL
DOI: 10.1002/ptr.4672
Keywords
damnacanthal; anthraquinone; preferential cytotoxicity; Garcinia huillensis; pancreatic cancer
Categories
Funding
- Ministry of Health and Welfare
Ask authors/readers for more resources
Screening of eight Congolese medicinal plants showed that the CHCl3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 mu g/mL and 13.8 mu g/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 mu g/mL) and Securidaca longepedunculata (PC50 = 23.4 mu g/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC50 = 4.46 mu m and 3.77 mu m, respectively). Copyright (c) 2012 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available