Journal
PHYTOTHERAPY RESEARCH
Volume 25, Issue 10, Pages 1558-1563Publisher
WILEY
DOI: 10.1002/ptr.3551
Keywords
apoptosis; cell cycle; C-33A; Xylopia aethiopica
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Funding
- CSIR Network [IAP-0001]
- MoES
- INSA JRD-TATA
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The anticancer potential of Xylopia aethiopica fruit extract (XAFE), and the mechanism of cell death it elicits, was investigated in various cell lines. Treatment with XAFE led to a dose-dependent growth inhibition in most cell lines, with selective cytotoxicity towards cancer cells and particularly the human cervical cancer cell line C-33A. In this study, apoptosis was confirmed by nuclear fragmentation and sub-G(0)/G(1) phase accumulation. The cell cycle was arrested at the G(2)/M phase with a decreased G(0)/G(1) population. A semi-quantitative gene expression study revealed dose-dependent up-regulation of p53 and p21 genes, and an increase in the Bax/Bcl-2 ratio. These results indicate that XAFE could be a potential therapeutic agent against cancer since it inhibits cell proliferation, and induces apoptosis and cell cycle arrest in C-33A cells. Copyright (C) 2011 John Wiley & Sons, Ltd.
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