Journal
PHYTOTHERAPY RESEARCH
Volume 26, Issue 7, Pages 1048-1052Publisher
WILEY-BLACKWELL
DOI: 10.1002/ptr.3698
Keywords
artichoke; hamster; cholesterol; bile acids
Categories
Funding
- Pharmazeutische Fabrik Montavit Ges.m. b. H., Austria
Ask authors/readers for more resources
A study was conducted in hamsters to determine if artichoke leaf extract (ALE) could lower plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols. Sixty-four Golden Syrian hamsters (8?week old) were fed control diet or a similar diet containing ALE (4.5?g/kg diet) for 6?weeks. No significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were found after 21?days for ALE-fed animals compared with controls. But after 42?days, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls. Total neutral sterol and bile acids concentrations increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls. The ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42?days. Copyright (c) 2011 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available