Journal
PHYTOTHERAPY RESEARCH
Volume 26, Issue 2, Pages 308-312Publisher
WILEY-BLACKWELL
DOI: 10.1002/ptr.3560
Keywords
hesperidin; central nervous system; depressant action; anxiolytic activity; intraperitoneal treatment; oral intake
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Funding
- CONICET [5537/05, 112-200801-01150]
- UBA, Argentina [B113, B097]
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Hesperidin (HN) is a flavanone glycoside abundantly found in citrus fruits. This flavonoid mediated central nervous system activity following intraperitoneal (i.p.) acute treatment. The responses of mice after the chronic i.p. (4 and 30mg/kg/day) or the oral intake administration of this drug (20, 50 and 100 mg/kg/day) were studied by using the holeboard, the plus-maze and the locomotor activity tests. Hesperidin, chronically administered by the i.p. route, exerted a decrease in the locomotor and exploratory activities, thus evidencing a depressant activity. In turn, the chronic oral intake of this flavonoid induced anxiolytic-like effects. These varied responses could be attributed to the different routes of administration that could lead to the production of diverse active metabolites. Copyright (C) 2011 John Wiley & Sons, Ltd.
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