Journal
PHYTOTHERAPY RESEARCH
Volume 25, Issue 8, Pages 1246-1249Publisher
WILEY
DOI: 10.1002/ptr.3404
Keywords
antiparasitic; Mimulus bigelovii; geranyl flavonoids; Leishmania; Trypanosoma; Phrymaceae
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Bioactivity-directed fractionation of the MeOH fraction of the extract of Mimulus bigelovii by means of an axenic Leishmania amastigote assay and chromatographic techniques resulted in the isolation of four C-geranyl flavanones, diplacone (1), 3'-O-methyldiplacone (2), 4'-O-methyldiplacone (3), 3'-O-methyldiplacol (4), together with a geranylated flavone, cannflavin A (5). These compounds were separated from M. bigelovii for the first time. All compounds showed moderate antileishmanial activity against axenic Leishmania donovani amastigotes with IC50 values ranging from 4.8 to 14.6 mu g/mL. The compounds were also tested against the related kinetoplastid parasite Trypanosoma brucei brucei and they showed activity with IC50 values ranging from 1.4 to 7.2 mu g/mL. Copyright (C) 2011 John Wiley & Sons, Ltd.
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