Journal
PHYTOTHERAPY RESEARCH
Volume 26, Issue 8, Pages 1119-1125Publisher
WILEY
DOI: 10.1002/ptr.3689
Keywords
genistein; radiation; testis; sperm; radioprotection; mice
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Funding
- Ministry of Education, Science and Technology, Korea [50496-2011, 50596-2011]
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The present study investigated the radioprotective effect of a multifunctional soy isoflavone, genistein, with the testicular system. Genistein was administered (200?mg/kg body weight) to male C3H/HeN mice by subcutaneous injection 24?h prior to pelvic irradiation (5?Gy). Histopathological parameters were evaluated 12?h and 21?days post-irradiation. Genistein protected the germ cells from radiation-induced apoptosis (p?
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