Journal
PHYTOTHERAPY RESEARCH
Volume 26, Issue 7, Pages 964-968Publisher
WILEY-BLACKWELL
DOI: 10.1002/ptr.3663
Keywords
Phyllantus niruri L; lignans; nirtetralin B; anti-HBV
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Funding
- National Natural Science Foundation of China (NSFC) [30660216, 81060261]
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One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC50 values for HBsAg of 9.5?mu m (nirtetralin A), 16.7?mu m (nirtetralin B) and 97.2?mu m (nirtetralin), IC50 values for HBeAg of 17.4?mu m (nirtetralin A), 69.3?mu m (nirtetralin B) and 232.0?mu m (nirtetralin), respectively. Copyright (c) 2011 John Wiley & Sons, Ltd.
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