Journal
PHYTOTHERAPY RESEARCH
Volume 25, Issue 1, Pages 46-48Publisher
WILEY
DOI: 10.1002/ptr.3159
Keywords
Erythrina caffra; Fabaceae; flavonoids; prenylated flavonoids; isoflavonoids; antibacterial
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Funding
- National Research Foundation, Pretoria
- University of KwaZulu-Natal, South Africa
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The antibacterial activity of the stem bark of Erythrina caffra Thunb. was investigated against different bacterial strains. The antibacterial activity was determined by a micro broth dilution assay. Antibacterial compounds were isolated and identified using a Bruker Avance III LPO NMR spectrometer. Four known flavonoids, abyssione-V 4'-O-methyl ether, 6,8-diprenylgenistein, alpinumisoflavone and burttinone, were isolated. All the compounds were active against both Gram-negative and Gram-positive bacteria. The minimum inhibitory concentration values obtained (MIC) ranged from 3.9 mu g/mL to 125 mu g/mL. This is the first report of antibacterial activity of burttinone and the isolation of these compounds from E. caffra. Copyright (C) 2010 John Wiley & Sons, Ltd.
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