Journal
PHYTOTHERAPY RESEARCH
Volume 24, Issue 12, Pages 1844-1849Publisher
WILEY
DOI: 10.1002/ptr.3206
Keywords
oxymatrine; arrhythmia; APD; ion channel
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Funding
- Natural Science Foundation of Heilongjiang Province of China [D200960]
- Education Department of Heilongjiang Province of China [11531082]
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Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular system. This study was designed to evaluate the antiarrhythmic effects as well as the electrophysiological properties of oxymatrine. The antiarrhythmic activity of oxymatrine was observed in a rat model of arrhythmia induced by coronary ligation. Action potential duration (APD), L-type calcium current (ICa-L), transient outward potassium current (I-t0) and inward rectifier potassium current (I-K1) in rat ventricular myocytes were recorded by utilizing the whole cell patch-clamp technique. The results showed that administration of oxymatrine significantly delayed the onset of ventricular arrhythmia, decreased the duration of ventricular arrhythmia and reduced the arrhythmia score of arrhythmic rats. The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of ICa-L, enhancement of I-t0 and inhibition of I-K1. Copyright (C) 2010 John Wiley & Sons, Ltd.
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