Journal
PHYTOTHERAPY RESEARCH
Volume 25, Issue 3, Pages 338-342Publisher
WILEY
DOI: 10.1002/ptr.3260
Keywords
forsythoside A; IBV; inhibition; CEK cell; in vitro
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Funding
- Natural Science Foundation of Beijing [6092004]
- National Natural Science Foundation [30771625, 30972215]
- Academic Human Resource Development in Institutions of Higher Learning
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Forsythoside A is a polyphenolic constituent of the fruits of Forsythia suspensa Vahl. which is widely used as an antiinflammatory agent in traditional Chinese medicine. In the present study, the effects of forsythoside A on cell infection by avian infectious bronchitis virus were assessed. A real-time fluorescence quantitative PCR assay was used to determine mRNA content of IBV N gene. The pretreatment of cells with forsythoside A, adding forsythoside A post infection of cells, and treatment of virus with forsythoside A were analysed. The inhibitory effect of forsythoside A was confirmed by infecting primary chicken embryo kidney cells. Infected cells were inhibited by forsythoside A treatment. The data indicated that forsythoside A has the potential to prevent IBV infection in vitro. Copyright (c) 2010 John Wiley & Sons, Ltd.
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