Journal
PHYTOTHERAPY RESEARCH
Volume 24, Issue 10, Pages 1447-1450Publisher
WILEY-BLACKWELL
DOI: 10.1002/ptr.3153
Keywords
Laurencia majuscula; hexadecyl-1-O-alpha-L-arabinopyranoside; antitumor; cell proliferation; cell cycle arrest
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Funding
- National High Technology Development Project (863 Project) [2006AA09Z408 GDSFC 06025194, 2005A30503001, 2006Z3-E4041]
- National Natural Science Fund [20772048]
- Medical Research Fund of Guangdong Province [B2006084]
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A new arabinopyranoside was isolated from the alga Laurencia majuscula (Harvey) Lucas, collected from the Xisha Islands in the South China Sea. Its structure was elucidated as hexadecyl-1-O-alpha-L-arabinopyranoside by spectroscopic analysis. It was found that arabinopyranoside had significant antitumor activity in LOVO and Bel-7402 cell lines. Flow cytometric analysis showed that arabinopyranoside arrested the cell cycle in the G2/M phase. Western blotting demonstrated that the protein expression of CDK1 and cyclin A related to the G2/M phase decreased markedly with arabinopyranoside treatment, with slight changes in cyclin B1 expression. Taken together, the findings identify a potential new antitumor therapeutic arabinopyranoside isolated from red alga Laurencia majuscula. Copyright (c) 2010 John Wiley & Sons, Ltd.
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