Journal
PHYTOTHERAPY RESEARCH
Volume 23, Issue 11, Pages 1516-1520Publisher
WILEY
DOI: 10.1002/ptr.2492
Keywords
Vitex agnus-castus; Verbenaceae; flavonoid; casticin; immunomodulatory properties; monocyte oxidative burst inhibition
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Funding
- Jinnah Government College. Nazimabad, Karachi, Pakistan
- Higher Education Commission, Islamabad, Pakistan
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Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10(-8) m) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T-cell (PMBC). Copyright (C) 2009 John Wiley & Sons, Ltd.
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