Journal
PHYTOTHERAPY RESEARCH
Volume 22, Issue 7, Pages 985-989Publisher
WILEY
DOI: 10.1002/ptr.2452
Keywords
oxymatrine; myocardial infarction; apoptosis; Bcl-2; Fas; intracellular Ca2+
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Oxymatrine has been demonstrated to have a variety of pharmacological actions. Accumulating evidence indicates that oxymatrine may exert a protective effect on the cardiovascular system. The study was designed to explore the possible role of oxymatrine against myocardial ischemic damage and several related signaling pathways as potential mechanisms. The protective properties of oxymatrine were studied in a rat model of acute myocardial infarction due to permanent ligation of the left anterior descending coronary artery. The results showed that administration of oxymatrine relieved myocardial injuries during ischernia, and this was achieved by protecting cardiomyocytes from apoptotic death. The beneficial effects of oxymatrine were likely mediated by an inhibition of lipid peroxidation (MDA production) and an increase in endogenous antioxidant activity (SOD), activation of the survival signaling molecule (Bcl-2), and a reduction of apoptotic mediator (Fas) and intracellular Ca2+ overload. Copyright (c) 2008 John Wiley & Sons, Ltd.
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