Journal
PHYTOTHERAPY RESEARCH
Volume 22, Issue 9, Pages 1149-1153Publisher
WILEY
DOI: 10.1002/ptr.2368
Keywords
Porphyra yezoensis; acetaminophen; GSH
Categories
Funding
- Marine Bioprocess Research Center of the Marine Bio 21 Center [M2007-03]
- Ministry of Maritime Affairs and Fisheries, Republic of Korea
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Seaweeds contribute to the maintenance of health through their nutritional and medicinal properties. The effects of PYP, a 14 kDa protein isolated from a hot-water extract of the marine alga Porphyra yezoensis, on AAP-induced liver injury in rats was evaluated. AAP induced acute liver injury and AAP-induced hepatotoxicity is the leading cause of liver failure. In this study, male Sprague-Dawley rats were assigned to one of three treatment groups: control, AAP, or AAP + PYP. Compared with the control group, liver tissue from the AAP group showed increased levels of caspase-3 activity and DNA fragmentation, decreased levels of GSH and increased serum GOT/GPT levels. In contrast, treatment with AAP + PYP produced levels of caspase-3 activity, DNA fragmentation, GSH and GOT/GPT that matched the values seen in the control group. It is concluded that PYP may prevent AAP-induced liver injury. Copyright (c) 2008 John Wiley & Sons, Ltd.
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