Journal
PHYTOMEDICINE
Volume 20, Issue 10, Pages 865-873Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2013.03.006
Keywords
Xanthatin; Apoptosis; Wnt/beta-catenin signaling; Melanoma
Categories
Funding
- JiangSu Province Hospital Of TCM, Nanjing, China
Ask authors/readers for more resources
Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of beta-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/beta-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. (C) 2013 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available