Journal
PHYTOMEDICINE
Volume 20, Issue 6, Pages 537-542Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2012.12.019
Keywords
Crocin; Streptozotocin (STZ); Spatial memory; Oxidative stress
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Funding
- Physiology Research Center [PRC-69]
- Ahvaz Jundishapur University of Medical Sciences (Iran)
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Intracerebroventricular (ICV) streptozotocin (STZ) has been shown to cause cognitive impairment, associated with free radical generation. In this study, we evaluated the effects of crocin on cognitive performance in ICV STZ-lesioned rats (3 mg/kg bilaterally, on day 1 and 3). Crocin (100 mg/kg, p.o.) was administered for 21 consecutive days, starting 1 h prior to the first dose of STZ. Cognitive performance was assessed using Morris water maze task while the parameters of oxidative stress assessed, were malondialdehyde (MDA) and total thiol levels besides glutathione peroxidase (GPx) activity. STZ-lesioned rats showed a severe deficit in memory associated with elevated MDA levels, reduced GPx activity and total thiol content. Crocin treatment improved cognitive performance and resulted in a significant reduction in MDA levels and elevation in total thiol content and GPx activity. This study demonstrates that crocin may have beneficial effects in the treatment of neurodegenerative disorders such as Alzheimer's disease. (C) 2013 Elsevier GmbH. All rights reserved.
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