Journal
PHYTOMEDICINE
Volume 20, Issue 3-4, Pages 303-309Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2012.11.004
Keywords
G. biloba leaves extract; EGb 761; LPS; Acute lung injury; Antioxidative enzymes; NF kappa B; MMP-9
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Funding
- National Science Council of the Republic of China, Taiwan [NSC99-2320-B-040-012-MY3]
- Changhua Christian Hospital
- Chung Shan Medical University of the Republic of China, Taiwan [CSMU-CCH-101-01]
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Acute lung injury (ALI) presents high mortality and morbidity clinically and by far no effective preventive strategy has been established. Extract of Ginkgo biloba leaves, EGb 761, is a complex mixture that possesses several clinical beneficial effects such as anti-oxidation, anti-inflammation, anti-tumor, and cardioprotective property. With EGb 761 pretreatment, both lipopolysaccharide (LPS)-induced protein leakage and neutrophil infiltration, and LPS-induced inflammatory responses including increased myeloperoxidase (MPO) activity, lipid peroxidation, and metalloproteinase (MMP)-9 activity, were inhibited; LPS-suppressed activation of antioxidative enzymes (AOE) were reversed; and not only the phosphorylation of NF-kappa B but also the degradation of its inhibitor, I kappa B, were suppressed. These results suggested that the protection mechanism of EGb 761 is by inhibition of NF kappa B activation, possibly via the up-regulation of antioxidative enzymes. More studies are needed to further evaluate whether EGb 761 is a suitable candidate as an effective dietary strategy to reduce the incidence of endotoxin-induced ALI. (C) 2012 Elsevier GmbH. All rights reserved.
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