Journal
PHYTOMEDICINE
Volume 19, Issue 8-9, Pages 836-839Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2012.03.010
Keywords
Citrus aurantifolia; Essential oil; Acetylcholinesterase; Butyrylcholinesterase; Ellman's method
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Funding
- Thailand Research Fund (TRF) [IUG 5080012]
- RGJ-PhD program [5.G.CM/50/D.1]
- Graduate school, Chiang Mai University
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Inhibition of cholinesterase has attracted much attention recently because of its potential for the treatment of Alzheimer's disease. In this work, the anticholinesterase activities of plant oils were investigated using Ellman's calorimetric method. The results indicate that essential oils obtained from Melissa officinalis leaf and Citrus aurantifolia leaf showed high acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. C. aurantifolia leaf oil revealed in this study has an IC50 value on acetylcholinesterase and butyrylcholinesterase of 139 +/- 35 and 42 +/- 5 mu g/ml, respectively. GC/MS analysis revealed that the major constituents of C. aurantifolia leaf oil are monoterpenoids including limonene, L-camphor, citronellol, o-cymene and 1,8-cineole. (C) 2012 Elsevier GmbH. All rights reserved.
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