Journal
PHYTOMEDICINE
Volume 18, Issue 6, Pages 458-463Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2010.08.015
Keywords
Dioscorea zingiberensis CH Wright; Diosgenin; Anti-thrombosis; Platelet aggregation; Bleeding time; Anticoagulation
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Funding
- China National 11.5 Foundation [2006BAB04A14]
- National 863 projects [2006AA03Z356, 2007AA021800]
- Sichuan Province Foundation [2008SZ 0024]
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Thrombus formation in blood vessel plays an important role in the pathogenesis and progression of atherosclerosis and cardiovascular diseases. Extract of Dioscorea zingiberensis C.H. Wright (D. zingiberensis) is demonstrated to posses activities for curing cardiovascular diseases such as coronary heart disease and angina pectoris. However, there were few studies on anti-thrombosis activity of it. We investigated the anti-thrombosis effect of diosgenin from D. zingiberensis (Dio) in vitro and in vivo on inferior vena cava ligation thrombosis rat model and pulmonary thrombosis mice model. We evaluated the protective effect of Dio by measuring the platelet aggregation, activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT) and the venous thrombosis in rats and the bleeding time, clotting time and protection rate in mice. Results showed that Dio inhibited platelet aggregation, thrombosis and prolonged APTT, PT and IT in rats in a dose-dependent manner. They also prolonged the bleeding time, clotting time and increased protection rate in mice in a dose-dependent manner. Taken together, these findings suggested that Dio which contained 95% diosgenin had anti-thrombosis activity. Dio executives the anti-thrombosis activity through improving the anticoagulation function, inhibiting platelet aggregation and thrombosis. (C) 2010 Elsevier GmbH. All rights reserved.
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