Journal
PHYTOMEDICINE
Volume 18, Issue 1, Pages 25-31Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2010.05.013
Keywords
Polygonatum cyrtonema lectin (PCL); Calanthus nivalis agglutinin (GNA)-related lectin; Ophiopogon japonicus lectin (OJL); Sugar-binding motif; Apoptosis; Caspase
Categories
Funding
- National Natural Science Foundation of China [30670469, 30970643]
Ask authors/readers for more resources
Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins, has been well-known to possess several biological functions including apoptosis-inducing activities. However, the precise mechanisms of GNA-related lectins to induce apoptosis remains to be clarified. In this study, we showed that Polygonatum cyrtonema lectin (PCL) and Ophiopogon japonicus lectin (OJL), the two mannose-binding GNA-related lectins, could induce murine fibrosarcoma L929 cell apoptosis. In addition, we found that there was a close link between their sugar-binding and apoptosis-inducing activities. Interestingly, we further confirmed that the mechanism of lectin-induced apoptosis was a caspase-dependent pathway. Moreover, we found that the two lectins could amplify tumor necrosis factor alpha (TNF alpha)-induced apoptosis. Taken together, these findings would open a new perspective for GNA-related lectins as potential anti-tumor agents. Crown Copyright (C) 2010 Published by Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available