Journal
PHYTOMEDICINE
Volume 17, Issue 14, Pages 1082-1085Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2010.05.004
Keywords
Hericium erinaceus; Hericenone; Platelet aggregation; Collagen; Integrin alpha 2/beta 1
Categories
Funding
- Japan Society for Promotion of Science [20790053]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18058002, 20054002]
- Hokuto Life Science Foundation
- Grants-in-Aid for Scientific Research [20790053, 20054002, 18058002] Funding Source: KAKEN
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Platelet aggregation in the blood vessel causes thrombosis. Therefore, inhibitors of platelet aggregation promise to be preventive or therapeutic agents of various vascular diseases, including myocardial infarction and stroke. In the present study, we found that hericenone B had a strong anti-platelet activity and it might be a novel compound for antithrombotic therapy possessing a novel mechanism. Prior to this study, we examined anti-platelet aggregation activity of ethanol extracts of several species of mushrooms, and found that extract of Hericium erinaceus potently inhibited platelet aggregation induced by collagen. Therefore, we first fractionated the ethanol extract of H. erinaceus to identify the active substances. The anti-platelet activity of each fraction was determined using washed rabbit platelets. As a result, an active component was isolated and identified as hericenone B. Hericenone B selectively inhibited collagen-induced platelet aggregation, but it did not suppress the aggregation induced by U46619 (TXA(2) analogue), ADP, thrombin, or adrenaline. Furthermore, hericenone B did not inhibit arachidonic acid- or convulxin (GPVI agonist)-induced platelet aggregation. Therefore, hericenone B was considered to block collagen signaling from integrin alpha 2/beta 1 to arachidonic acid release. Moreover, we found that collagen-induced aggregation was inhibited by hericenone B in human platelets, similar to in rabbit platelets. (C) 2010 Elsevier GmbH. All rights reserved.
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