Journal
PHYTOMEDICINE
Volume 17, Issue 6, Pages 397-403Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2010.01.012
Keywords
Mice; Anxiety; Exploratory activity; GABA; Melissa officinalis L.
Categories
Funding
- Naturex
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This study aimed to determine the effects of chronic (15 consecutive days of treatment) per os administration of Melissa officinalis L. extract (Cyracos (R), Naturex) on anxiety-like reactivity in mice As measured by HPLC, Cyracos (R) contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-ammobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007, Awad et al., 2009). Thus, we evaluated Cyracos (R) use in independent groups of C57BL/6 mice with regard to anxiety-like reactivity in an elevated plus maze and an open field task We found that Cyracos (R) significantly reduced anxiety-like reactivity in the elevated plus maze dose-dependently, but no significant effect was observed in the open field task Parallel experiments in independent groups of mice showed that the Cyracos (R) dose at which it exerted anxiolytic-like effects in the elevated plus maze did not alter exploratory or circadian activities. Therefore, our results demonstrate that Cyracos (R) has anxiolytic-like effects under moderate stress conditions and does not alter activity levels (C) 2010 Elsevier GmbH All rights reserved
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