Journal
PHYTOMEDICINE
Volume 16, Issue 2-3, Pages 215-221Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2008.08.005
Keywords
Chinese medicine formula; Guan-Xin-Er-Hao; Salvia miltiorrhiza; Ligusticum chuanxiong; Paeonia lactiflora; Carthamus tinctorius; Dalbergia odorifera; Ischemic heart disease; Oxidative stress
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Funding
- National Science Fund for Distinguished Young Scholars of China [30325045]
- Natural Science Foundation of China [30572339]
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Guan-Xin-Er-Hao (GXEH) is a Chinese medicine formula for treating ischemic heart diseases (IHD) and has a favorable effect. Our aim was to examine whether or not acute oral GXEH could protect the heart against myocardial infarction and apoptosis in acute myocardial ischemic rats. If so, we would explain the antioxidative mechanism involved. The left anterior descending coronary artery was occluded to induce myocardial ischemia in hearts of Sprague-Dawley rats. At the end of the 3 h ischemic period (or 24h for infarct size), we measured the myocardial infarct size, myocardial apoptosis and the activities of antioxidative enzymes. GXEH reduced infarct size, myocardial apoptosis and the serum level of malondialdehyde (MDA), increased the activities of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and GSH-peroxidase (GPX) activities and the serum level of glutathione (GSH). GXEH exerts significant cardioprotective effects against acute ischemic myocardial injury in rats, likely through its antioxidation and antilipid peroxidative properties, and thus may be used as a promising agent for both prophylaxis and treatment of IHD. Crown Copyright (C) 2008 Published by Elsevier GmbH. All rights reserved.
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