Journal
PHYTOMEDICINE
Volume 16, Issue 8, Pages 761-767Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2008.12.019
Keywords
Isoquercitrin; Hyptis fasciculata; Antioxidant activity; Brazilian plants; Oxidative stress
Categories
Funding
- FAPERJ
- CAPES
- CNPq and FAPESP [04-10067/6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [04/10067-6] Funding Source: FAPESP
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Reactive oxygen species (ROS) are thought to underline the process of ageing and the pathogenicity of various diseases, such as neurodegenerative disorders and cancer. The use of traditional medicine is widespread and plants still present a large source of natural antioxidants that might serve as leads for the development of novel drugs. In this paper, the alcoholic extract from leaves of Hyptis fasciculata, a Brazilian medicinal plant, and isoquercitrin, a flavonoid identified in this species, showed to be active as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavengers. The extract of Hyptis fasciculata and isoquercitrin were also able to increase tolerance of the eukaryotic microorganism Saccharomyces cerevisiae to both hydrogen peroxide and menadione, a source of superoxide. Cellular protection was correlated with a decrease in oxidative stress markers, such as levels of ROS, protein carbonylation and lipid peroxidation, confirming the antioxidant potential of Hyptis fasciculata and isoquercitrin. (C) 2009 Elsevier GmbH. All rights reserved.
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