Journal
PHYTOMEDICINE
Volume 15, Issue 12, Pages 1135-1139Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2008.06.005
Keywords
Crocins; Anxiety; Light/dark test; Motility; Rat
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Funding
- Research Committee of the University of Thessaly [3219]
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Crocus sativus L. is a plant cultivated in various parts of the world. Crocins are among the active components of Crocus sativus L. The present study was designed to investigate in the rat whether or not crocins possess anxiolytic properties. For this aim, the light/dark test was selected. Either crocins, at a dose which did not influence animals' motor activity (50 mg/kg), or diazepam (1.5 mg/kg), significantly increased the latency to enter the dark compartment and prolonged the time spent in the lit chamber in the rats. Conversely, lower doses of crocins (15-30 mg/kg) did not substantially modify animals' behaviour. The present results indicate that treatment with these active constituents of Crocus sativus L. induce anxiolytic-like effects in the rat. (C) 2008 Elsevier GmbH. All rights reserved.
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