Journal
PHYTOMEDICINE
Volume 15, Issue 10, Pages 882-885Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2007.12.001
Keywords
Hippeastrum vittatum; Amaryllidaceae; Cytotoxic activity; Alkaloids; Montanine; Vittatine
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The dichloromethane and n-butanol extracts obtained from fresh bulbs of Hippeastrum vittatum (Amaryllidaceae), collected in Southern Brazil, were evaluated for their cytotoxic activity in vitro against five human cell lines (HT29 colon adenocarcinoma, H460 non-small cell lung carcinoma, RXF393 renal cell carcinoma, MCF7 breast cancer, and OVCAR3 epithelial ovarian cancer), using the sulphorhodamine B assay. Both extracts showed potential antiproliferative activity. From CH2Cl2 fraction, three alkaloids were isolated: lycorine, vittatine and montanine. The two last compounds were submitted to the antiproliferative assay and the highest level of cytotoxicity was found for the alkaloid montanine. (C) 2007 Elsevier GmbH. All rights reserved.
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