Journal
PHYTOCHEMISTRY REVIEWS
Volume 9, Issue 3, Pages 425-474Publisher
SPRINGER
DOI: 10.1007/s11101-010-9183-z
Keywords
Cytotoxic mechanisms; Glycosides; Sar; Steroid; Triterpenoid
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Funding
- Ministry of Science and Higher Education, Poland [N N405 297636]
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Saponins are natural glycosides which possess a wide range of pharmacological properties including cytotoxic activity. In this review, the recent studies (2005-2009) concerning the cytotoxic activity of saponins have been summarized. The correlations between the structure and the cytotoxicity of both steroid and triterpenoid saponins have been described as well as the most common mechanisms of action.
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