Journal
PHYTOCHEMISTRY REVIEWS
Volume 8, Issue 2, Pages 461-472Publisher
SPRINGER
DOI: 10.1007/s11101-009-9131-y
Keywords
Marine natural products; Tunicates; Ascidians; Cytotoxicity; Anticancer activity
Categories
Ask authors/readers for more resources
Ascidians, invertebrates belonging to the subphylum Urochordata (Tunicata), are renowned for their great chemical diversity, and during the last 25 years, they have been shown to produce an array of cytotoxic molecules. Among the first six marine-derived compounds that have reached clinical trials as antitumor agents, three are derived from ascidians, as evidence of the high potential of these organisms as a new source of antitumor compounds. Reported in this communication are some recent results on the chemistry of Mediterranean ascidians; a number of new molecules with different structural features but all endowed with antiproliferative or cytotoxic activity are discussed. These results strongly evidence the highly significant role that Mediterranean ascidians natural products could play in anticancer drug discovery and development process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available