Journal
PHYTOCHEMISTRY LETTERS
Volume 8, Issue -, Pages 92-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2014.02.008
Keywords
Datura metel L.; Solanaceae; Withanolides; Antiproliferative; Immunosuppressive
Categories
Funding
- Major State Basic Research Development Program of China (973 Program) [2006CB504708]
- National Natural Science Foundation of China [30371736, 30672633]
- Special Fund Project of National Excellent Doctoral Dissertation of China [200980]
- General Program Projects Funding of Heilongjiang University of Chinese Medicine [200916]
Ask authors/readers for more resources
Two new withanolides baimantuoluoside H (1) and baimantuoluoline K (2), and one known withanolide glycoside (3) were isolated and identified from the ethyl acetate-soluble fraction of ethanol extract of Datura metel seeds. The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and mass spectrometry. All isolated compounds were evaluated for their antiproliferative activity against human gastric adenocarcinoma (SGC-7901), human hepatoma (Hepg2), and human breast cancer (MCF-7) cells, as well as their immunosuppressive properties. It was determined that compounds 1-3 exhibited medium antiproliferative and potential immunosuppressive effects. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
