Journal
PHYTOCHEMISTRY LETTERS
Volume 10, Issue -, Pages 5-9Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2014.06.014
Keywords
Diaporthaceae sp.; Marine-derived fungus; Pentacyclic cytochalasin; Ethyl trihydroxytridecatrienoate; Antibacterial activity
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Funding
- Thailand Research Fund (TRF) for the TRF Senior Research Scholar [RTA5480002]
- TRF through the Royal Golden Jubilee Ph.D. program [PHD/0231/2551]
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A new pentacyclic cytochalasin (diaporthalasin, 1) and a new ethyl trihydroxytridecatrienoate (diaporthacol, 2) together with five known compounds, R-mevalonolactone (4), dothiorelone C (5), (4S, 7S, 13S)-4,7-dihydroxy-1,3-tetradeca-1,5-dienolide (6), 4 beta-acetoxy-9 beta, 10 beta, 15 alpha-trihydroxyprobotrydial (7) and O-methyldihydrobotrydial (8) were isolated from the marine-derived fungus Diaporthaceae sp. PSU-SP2/4. The structures were established by spectroscopic techniques. Compound 1 displayed significant antibacterial activity against both Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 2 mu g/mL. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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