Journal
PHYTOCHEMISTRY LETTERS
Volume 7, Issue -, Pages 35-37Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2013.09.010
Keywords
Pestalotiopsis vaccinii; Pestalamine A; Cytotoxicity
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Funding
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- National Key Basic Research Program of China [2010CB833800, 2011CB915503]
- Knowledge Innovation Program of Chinese Academy of Sciences [SQ201019, SQ201117]
- National Natural Science Foundation of China [41376162, 213021983, 31270402, 21172230]
- Guangdong Province-CAS Joint Research Program [2012B091100264]
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A new aromatic amine named pestalamine A (1), as well as a known diketopiperazine (2) and four known phenol or aromatic amine derivatives (3-6) were isolated from mangrove-derived endophytic fungus Pestalotiopsis vaccinii. The structure of pestalamine A (1) was determined by spectroscopic methods, especially 2D NMR analyses. Pestalamine A (1) showed moderate cytotoxicities against MCF-7, HeLa, and HepG2 human cancer cell lines with IC50 values of 40.3, 22.0, and 32.8 mu M, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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