Journal
PHYTOCHEMISTRY LETTERS
Volume 6, Issue 4, Pages 539-543Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2013.07.003
Keywords
Aphanamixis grandifolia; Meliaceae; Limonoids; ECD calculation; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [21272275]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1193]
- Fundamental Research Funds for the Central Universities [JKY2011011]
- Syngenta Postgraduate Fellowship [SPF-048]
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Two new limonoids aphanamolides C (1) and D (2), together with two known limonoids aphanamolide A (3) and aphapolynin A (4), were isolated from the fruits of Aphanamixis grandifolia. Their structures were assigned on the basis of spectroscopic data, with the absolute configurations of 1 and 2 being established by electronic circular dichroism (ECD) spectroscopic analyses. Those limonoids varied in the ring A: aphanamolide C featured two oxygenated bridges, and aphanamolide D was the second example containing beta-hydroxy-alpha,beta:gamma,delta-dienoate moiety. The cytotoxic activities were also evaluated in vitro against four human cancer cell lines (MCF-7, A549, SMMC-7721, and HL-60). (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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