Journal
PHYTOCHEMISTRY LETTERS
Volume 6, Issue 2, Pages 246-252Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2013.02.006
Keywords
Inula britannica; Sesquiterpene lactones; Asteraceae; P-glycoprotein; Multi-drug resistance; Centrifugal partition chromatography
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Funding
- European Union [227448]
- Center for Biosystems Genomics part of the Netherlands Genomics Initiative
- Netherlands Metabolomics Center part of the Netherlands Genomics Initiative
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Five new sesquiterpene lactones (1-5) were isolated from Inula britannica collected in the wild from Serbia along with five known compounds (6-10). Sesquiterpene lactones were isolated using centrifugal partition chromatography followed by combination of flash chromatography and semi-preparative HPLC. Isolated compounds were screened for cytotoxic activity on four different human cancer cell lines and their multi-drug resistant counterparts, as well as on normal human keratinocytes. Sesquiterpene lactones showed similar cytotoxic activity toward drug sensitive and drug resistant cancer cell lines. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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