Journal
PHYTOCHEMISTRY LETTERS
Volume 5, Issue 2, Pages 271-275Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2012.01.010
Keywords
Ajuga decumbens; Abietane diterpenoids; Ajudecumins A-D; Cytotoxic
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Funding
- National Natural Science Foundation of China [30801431, 30925038]
- Scientific Research Foundation for the Excellent Middle-Aged and Youth Scientists of Shandong Province [BS2009YY001]
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Four new rearranged abietane diterpenoid hydroquinones, ajudecumins A-D (1-4), together with two known rearranged abietane diterpenoids, three neo-clerodane diterpenoids, four megastigmane derivatives, two flavonoids as well as a bisabolene sesquiterpenoid were isolated from the aerial parts of Ajuga decumbens. Their structures were established on the basis of extensive spectroscopic analysis and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Among the diterpenoids, compounds 1 and 3 exhibited moderate inhibitory activity on the proliferation of human breast cancer MCF-7 cells. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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