Journal
PHYTOCHEMISTRY LETTERS
Volume 5, Issue 1, Pages 165-169Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2011.12.002
Keywords
Oxirapentyns; Isaria felina; Mosher's method; X-ray
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Funding
- Russian Foundation for Basic Research (RFBR) [N 09-04-00388, 11-04-00772-a]
- Presidium RAS Molecular and Cell Biology''
- Russian Federation Program for Support of the Leading Scientific Schools [N 3531.2010.4]
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Three new highly oxygenated chromene derivatives, oxirapentyns B-D (1-3) and one known oxirapentyn A (4) were isolated from the lipophilic extract of the marine-derived fungus Isaria felina KMM 4639. The structures of compounds 1-3 were determined based on spectroscopic methods. The absolute configuration of oxirapentyn B (1) as 2R, 4S, 5S, 6S, 7R, 8S, 9S was established by a combination of modified Mosher's method, X-ray analysis, and NOESY data. Oxirapentyn A (4) showed weak cytotoxicity against SK-Mel-5, SK-Mel-28 human malignant melanoma, and T-47D human breast cancer cell lines. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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