Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp BCC45596

Three naturally new C-glycosylated benz[alpha]anthraquinone derivatives, urdamycinone E (1), urdamycinone G (2), dehydroxyaquayamycin (3) have been isolated from the marine Streptomycetes sp. BCC45596. Urdamycin E (4), the possible biosynthetic precursor of 1-3, has also been identified after a recultivation of the strain. These compounds (1-4) exhibited potent anti-Plasmodium palcifarum K1 strain with IC50 values in a range of 0.0534-2.93 mu g/mL and anti-Mycobacterium tuberculosis with minimum inhibition concentrations (MICs) in a range of 3.13-12.50 mu g/mL. Cytotoxicity against KB, MCF-7, NCI-H187, and Vero cells was also evaluated. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.