Journal
PHYTOCHEMISTRY LETTERS
Volume 4, Issue 2, Pages 97-100Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2010.11.007
Keywords
Cicuta virosa L.; Dimeric coumarin; MDR; K562; K562/A02
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Funding
- Natural Science Foundation of Shandong Province of PR China [Y2006C38, Y2008C98]
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A new dimeric coumarin, diarchangelicin A (1), together with 10 known coumarins, were isolated from the aerial parts of Cicuta virosa L. and their structures were elucidated by spectroscopic methods. In addition, the known compounds were evaluated for multidrug resistance reversing activity by using doxorubicin-resistant K562/A02 cells. Compounds 2 and 7 were endowed with remarkable MDR reversing effects. Crown Copyright (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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