Journal
PHYTOCHEMISTRY LETTERS
Volume 4, Issue 3, Pages 377-379Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2011.08.004
Keywords
Eupatorium coelestinum; Asteraceae; Amorphane sesquiterpene; Benzofuran; NF-kappa B
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Funding
- International Foundation for Science [F/4729-1]
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A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5 alpha,8 alpha-epoxy-4 alpha,6 beta-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-beta-D-glucopyranoside (2). Compounds 1 significantly inhibited NF-kappa B activity in TNF-alpha-stimulated HeLa cells with the IC50 of 12.4 mu M. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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