Journal
PHYTOCHEMISTRY LETTERS
Volume 4, Issue 3, Pages 328-332Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2011.07.001
Keywords
Inonotus obliquus; Hymenochaetaceae; Inonotsutriol D; Inonotsutriol E; Leukemia
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Funding
- Ministry of Education, Sciences, Sports and Culture, Japan
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Two new lanostane-type triterpenoids, inonotsutriols D (1) and E (2), were isolated from the sclerotia of Inonotus obliquus (Pers.: Fr.) Pil. (Japanese name: kabanoanatake; Russian name: chaga). Their structures were determined to be lanost-8-ene-3 beta,22R,24R-triol (1) and lanost-8-ene-3 beta,22R, 24S-triol (2) on the basis of spectral data, including 2D NMR analysis. In addition, major compounds, inotodiol (3), trametenolic acid (4), 3 beta-hydroxylanosta-8,24-dien-21-al (5), 21-hydroxylanosterol (6), inonotsuoxide A (7) and inonotsuoxide B (8) were identified, and all compounds, except 2, were evaluated for their cancer cell growth inhibitory activity against P388, HL-60, L1210 and KB cell lines. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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