Journal
PHYTOCHEMISTRY LETTERS
Volume 3, Issue 1, Pages 1-8Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2009.11.005
Keywords
Higher plants; Secondary metabolites; Anticancer agents; Compounds in clinical trials; Antineoplastic drug discovery
Categories
Funding
- National Cancer Institute [U19 CA52956, P01 CA125066]
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Plant secondary metabolites and their semi-synthetic derivatives continue to play an important role in anticancer drug therapy. In this short review, selected single chemical entity antineoplastic agents from higher plants that are currently in clinical trials as cancer chemotherapy drug candidates are described. These compounds are representative of a wide structural diversity. In addition, the approaches taken toward the discovery of anticancer agents from tropical plants in the laboratory of the authors are summarized. The successful clinical utilization of cancer chemotherapeutic agents from higher plants has been evident for about half a century, and, when considered with the promising pipeline of new plant-derived compounds now in clinical trials, this augurs well for the continuation of drug discovery research efforts to elucidate additional candidate substances of this type. (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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