Journal
PHYTOCHEMISTRY LETTERS
Volume 3, Issue 4, Pages 221-225Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2010.08.002
Keywords
Plectranthus saccatus; Plectranthus porcatus; Lamiaceae; Diterpenes; Beyerane; 13,16-Cycloabietane; Biological activity
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Funding
- Portuguese Fundacao para a Ciencia e a Tecnologia (FCT-MCES) [SFRH/BD/19250/2004]
- Spanish Ministerio de Ciencia e Innovacion [CTQ2009-10343]
- Consejeria de Educacion de la Comunidad de Madrid [CAPOTE-S2009/PPQ-1752]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/19250/2004] Funding Source: FCT
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Two new diterpenoids, ent-7 alpha-acetoxy-15-beyeren-18-oic acid and (13S,15S)-6 beta,7 alpha,12 alpha,19-tetrahydroxy-13 beta,16-cyclo-8-abietene-11,14-dione, have been isolated from Plectranthus saccatus and Plectranthus porcatus, respectively, and their structures were established by 1D and 2D NMR spectroscopic studies. The new diterpenes showed no activity against Gram-negative bacteria and Candida albicans (yeast strain). Among Gram-positive bacteria, the lower MIC value was 62.50 mu g/ml for the abietane derivative against Staphylococcus aureus ATCC 6538. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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