Journal
PHYTOCHEMISTRY LETTERS
Volume 2, Issue 4, Pages 141-143Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2009.04.002
Keywords
Flavanone; Artocarpus sepicanus; Antibacterial; Methicillin-resistant Staphylococcus aureus
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Funding
- United States Department of Agriculture, Agriculture Research Services [58-6408-7-012]
- NIH, NIAID, Division of AIDS [AI 27094]
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Bioassay-guided fractionation of the EtOH extract of Artocarpus sepicanus Diels leaves has led to the isolation of a new geranyl flavanone (1), along with the known compounds, afzelechin-3-O-alpha-L-rhamnopyranoside and beta-sitosterol glucoside. The structure of the new compound was established by UV, IR, HRESIMS, 1D and 2D NMR experiments. Antimicrobial testing of the three compounds indicated that 1 displayed a significant selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with IC50 and MIC values of 1.4 and 2.9 mu M, respectively. Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.
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