Journal
PHYTOCHEMISTRY LETTERS
Volume 2, Issue 3, Pages 114-118Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2009.03.002
Keywords
Centaurea africana; Asteraceae; Acylated flavonoid glucoside; Algerianin; Cytotoxic activity; Human leukaemia cell line; HL-60 cells
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Funding
- Algerian National Agency for Development of Health Research [05/01/02/05/146]
- programa de Iniciativa Comunitaria INTERREG IIIB Azores-Madeira-Canarias [04/MAC/3.5/C5]
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A new acylated flavonoid glucoside named algerianin 1 and a new as natural product, 4'-methyl gossypetin 2, together with 10 known compounds, isovanillic acid ethyl ester, beta-sitosterol, beta-sitosterol 3-O-glucoside, a mixture of alpha and beta-amyrin, 3'-hydroxyflindulatin, chrysoeriol, jaceidin, corniculatusin and centaurein were isolated from the ethanolic extract of the flowering and aerial parts of Centaurea africana Lamk var. africana (Bonnet) M., an endemic species to Algeria and Tunisia collected from El-Kala in the eastern Algeria. The structures were established by chemical and spectral analysis, mainly HREIMS, ESIMS, UV and NMR experiments (GOESY, COSY, ROESY, HSQC and HMBC). Algerianin showed cytotoxicity against the human myeloid leukaemia cell line HL-60. (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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