Journal
PHYTOCHEMISTRY LETTERS
Volume 1, Issue 4, Pages 183-187Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2008.09.002
Keywords
Combretum molle; Combretaceae; Triterpenoid; Saponins; Anti-inflammatory activity
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Funding
- COMSTECH (Committee on Scientific and Technological Cooperation of the Organization of Islamic Conference, Islamabad, Pakistan)
- IFS (International Foundation for Science, Stockholm, Sweden) [RGA No F/3976-1]
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A new oleanane-type triterpene saponin, beta-D-glucopyranosyl 2 alpha,3 beta,6 beta-trihydroxy-23-galloylolean-12-en-28-oate (1), together with four known oleanane-type pentacyclic triterpenoids, combregenin (2), arjungenin (3), arjunglucoside 1 (4). and combreglucoside (5) were isolated from the stem bark of Combretum molle. Their structures were established mainly on the basis of 1D and 2D NMR spectral data. Compounds 1-3 exhibited more significant activity against carrageenan-induced paw edema in rat compared to compounds 4 and 5. (C) 2008 Phytochemical Society of Europe Published by Elsevier B.V. All rights reserved.
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