Ramiferin, a bisphenol-sesquiterpene from the fungus Kionochaeta ramifera BCC 7585

A new bisphenol-sesquiterpene, ramiferin, together with two known sesquiterpene derivatives, pughiinin A and eupenifeldin, were isolated from the fungus Kionochaeta ramifera BCC 7585. Ramiferin displayed antimalarial activity with an IC(50) value of 6.3 mu M, and antitubercular activity with a minimum inhibitory concentration of 12.7 mu M. It was toxic against three cancer cell lines (BC, KB, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 9.1, 12.6, 13.0, and 9.7 mu M. (C) 2008 Phytochemical Society of Europe Published by Elsevier B.V. All rights reserved.