Journal
PHYTOCHEMISTRY
Volume 152, Issue -, Pages 45-52Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2018.04.017
Keywords
Trichoderma asperellum; Moniliaceae; Terpene; Bisabolane; Cyclonerane; Harziane
Categories
Funding
- National Natural Science Foundation of China [31670355]
- Natural Science Foundation for Distinguished Young Scholars of Shandong Province [JQ201712]
- Open Fund of Key Laboratory of Experimental Marine Biology, CAS [KF2017NO4]
- Youth Innovation Promotion Association of CAS [2013138]
- Self-Fund from Yantai Institute of Coastal Zone Research, CAS [Y755031012]
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Three undescribed bisabolane derivatives, trichaspin, trichaspsides A and B, three undescribed cyclonerane sesquiterpenes, 9-cycloneren-3,7,11-triol, 11-cycloneren-3,7,10-triol, and 7,10-epoxycycloneran-3,11,12-triol, and one undescribed harziane diterpene, 11-hydroxy-9-harzien-3-one, were obtained from the culture of Trichoderma asperellum cf44-2, an endophyte of the marine brown alga Sargassum sp.Their structures and relative configurations were assigned by analysis of 1D/2D NMR and MS data, and their absolute configurations were established by ECD or specific optical rotation data. Trichaspin features an unprecedented ethylated bisabolane skeleton, while trichaspsides A and B represent the first aminoglycosides of bisabolane and norbisabolane sesquiterpenes, respectively. Nine of the compounds were evaluated for inhibition of five marine-derived pathogenic bacteria and toxicity to a marine zooplankton. (C) 2018 Elsevier Ltd. All rights reserved.
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