Journal
PHYTOCHEMISTRY
Volume 153, Issue -, Pages 111-119Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2018.05.018
Keywords
Rhodomyrtus tomentosa; Myrtaceae; Phloroglucinol derivatives; Cytotoxic activity; Anti-inflammatory activity
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Funding
- National Natural Science Foundation of China [814731168, 81673319]
- Science and Technology Planning Project of Guangdong Province [2016A030303011, 2016B030301004]
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Seven undescribed phloroglucinol derivatives, tomentodiones N - T, and eleven known ones were isolated from Rhodomyrtus tomentosa. Tomentodione N is the first example of a beta-triketone unit coupled with an isoamyl alcohol through a furan fused-ring, and tomentodiones N, S, T were three racemates. The undescribed structures were elucidated by means of spectroscopic, X-ray diffraction, electronic circular dichroism calculation, and chemical methods. In addition, the isolated compounds were determined for the cytotoxic activities on HeLa cells and anti-inflammatory activities in LPS-stimulated RAW 264.7 cells.
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